"Triclosan is a multi-purpose biocide that is used in many personal care products,
including antibacterial handsoaps and toothpastes. The wide usage oftriclosan fosters its
dispersal into the enviro11l11ent, which might contribute to the ability of microorganisms
to become resistant to triclosan in addition to certain other biocides and clinical
antibiotics.
The aim of this study was to evaluate whether long-term exposure of two strains
of Staphylococclls epide]'midis to subinhibitory concentrations oftriclosan would select
for resistant mutants, and whether their ability to form polysaccharide biofilms lends to
this resistance. This study also aimed to detelmine whether a mutation in the triclosan
target was responsible for resistance, and to determine whether these mutants could
exhibit cross-resistance to chlorhexidine and clinical antibiotics. In addition, efflux
capability was assessed as a presumable resistance mechanism."
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